We know that consuming a diet high in fat causes obesity. Recently, French researchers discovered that eating a diet high in fat causes brain changes that can cause anxiety and depression. The good thing is to return to a healthy diet to reverse metabolic changes and mood problems. There is a controversy regarding whether type 2 diabetes and major depression are causally related. But the present study provides clear evidence that diabetes and depression are well correlated, especially when type 2 diabetes is induced by a prolonged high-fat diet. The high-fat diet is also associated with reduced levels of extracellular serotonin in the hippocampus. This is due to a greater sensitivity in the 5-HT1A autoreceptor. This mitigates the beneficial effect of antidepressants such as escitalopram. Only the treatment of diabetes may not be enough to treat anxiety in such patients. There is a defect in the brain that is much stronger than any defect in the periphery, it has to be corrected. The persistent behavioral problems that follow the high-fat diet should be addressed. Future studies should focus on the molecular mechanisms underlying the relationship and examine factors such as the role of polymorphisms and previous antidepressant therapy.
Video credits to Dr. Zulfiquar Ahmed YouTube channel